Axonal damage in acute multiple sclerosis lesions
نویسندگان
چکیده
منابع مشابه
Axonal damage in acute multiple sclerosis lesions.
One of the histological hallmarks of early multiple sclerosis lesions is primary demyelination, with myelin destruction and relative sparing of axons. On the other hand, it is widely accepted that axonal loss occurs in, and is responsible for, the permanent disability characterizing the later chronic progressive stage of the disease. In this study, we have used an antibody against amyloid precu...
متن کاملExtensive acute axonal damage in pediatric multiple sclerosis lesions.
OBJECTIVE Axonal damage occurs early in multiple sclerosis (MS) and contributes to the degree of clinical disability. Children with MS more often show disabling and polyfocal neurological symptoms at disease onset than adults with MS. Thus, axonal damage may differ between pediatric and adult MS patients. METHODS We analyzed axonal pathology in archival brain biopsy and autopsy samples from 1...
متن کاملAxonal Damage in Pediatric Multiple Sclerosis
Investigators from Georg August University, Gottingen, Germany, analyzed axonal pathology in brain biopsy and autopsy samples from 19 children with early multiple sclerosis (MS).
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Multiple sclerosis is a chronic inflammatory disease of the central nervous system, associated with demyelination and neurodegeneration. The mechanisms of tissue injury are currently poorly understood, but recent data suggest that mitochondrial injury may play an important role in this process. Since mitochondrial injury can be triggered by reactive oxygen and nitric oxide species, we analysed ...
متن کاملPlasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage.
Components of the plasminogen activator (PA) and matrix metalloprotease (MMP) cascade have been characterized in multiple sclerosis lesions by immunohistochemistry, enzyme-linked immunosorbent assay and enzyme activity assays in order to establish a functional role for the enzyme sequence in lesion development. Highly significant quantitative increases in urokinase PA (uPA), urokinase receptor ...
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ژورنال
عنوان ژورنال: Brain
سال: 1997
ISSN: 1460-2156
DOI: 10.1093/brain/120.3.393